Arg-Gly-Asp 99896-85-2RGD鑲

RGD鑲
鍒嗗瓙寮忥細C12H22N6O6 鍒嗗瓙閲忥細346.34

浜у搧鎻忚堪
RGD (Arg-Gly-Asp) 澶氳偨鏄涓绉嶇粏鑳炵矘闄勫簭鍒楋紝鍙浠ユā浠跨粏鑳炵矘闄勮泲鐧藉苟涓庢暣鍚堢礌缁撳悎銆
闈剁偣

IC50

浣撳栫爺绌
The RGD sequence is the cell attachment site of a large number of adhesive extracellular matrix, blood, and cell surface proteins, and nearly half of the over 20 known integrins recognize this sequence in their adhesion protein ligands. The RGD peptides and mimics can be used to probe integrin functions in various biological systems. Drug design based on the RGD structure may provide new treatments for diseases such as thrombosis, osteoporosis, and cancer.RGD peptide acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Research demonstrates that RGD peptides promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing.The RGD peptide can serve as a cell adhesion site of extracellular matrix, cell surface proteins, and integrins. In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion.
浣撳唴鐮旂┒

婧惰В鎬
姘 100 mM
绋冲畾鎬
2骞 -20°C绮夌姸锛6鏈-80°C婧朵簬DMSO